Principal Investigator, Oncology (Murrieta, CA)
Overview
We are searching for a Principal Investigator to lead oncology trials at a clinical research site in Murrieta. This is a critical role with direct impact on sponsor confidence, patient recruitment, and continuity of studies across an innovative therapeutic portfolio. The site, patients, space, and studies are all in place. What it needs now is a dedicated physician to serve as its medical anchor and grow it into full operation.
As Principal Investigator you will:
- Provide medical leadership across a range of oncology trials, ideally with broad medical oncology coverage spanning multiple tumour types.
- Serve as Principal Investigator on multiple ongoing studies at the same time, focusing on high quality day to day delivery on site.
- Build trust with patients and sponsors through clinical credibility and consistency.
- Work as the on site anchor within a wider, well established oncology network, with studies supplied through that network so you can concentrate on running them well rather than sourcing them.
- Oversee participant safety and welfare, obtain informed consent, assess compliance and response to therapy, and evaluate, document, and report all adverse events per protocol.
- Work alongside the on site nurse practitioner, coordinator, and clinical staff to deliver studies smoothly.
- Ensure adherence to FDA, ICH Good Clinical Practice, HIPAA, and IRB standards, oversee regulatory documentation, maintain confidentiality, and support quality and process improvement.
The Ideal Profile
- MD or DO, board certified in Medical Oncology or Hematology/Oncology strongly preferred.
- 5+ years of direct patient care experience.
- 2+ years of hands on clinical research experience as a Principal Investigator or Sub Investigator (essential, given you will be running studies independently on site).
- Oncology trial experience preferred.
- A collaborative, hands on style, comfortable being the invested day to day presence at a growing site.
The Role and Schedule
Full time is preferred, but there is real flexibility for the right candidate. We would consider a committed part time arrangement of two or three days per week, on weekdays during standard hours. The site currently runs one day a week purely because it lacks a dedicated physician, and the goal is to build it up to several days a week.
Why This Role?
- Step into a site that is ready to go, with patients, space, and active studies already in place, rather than building from scratch.
- Focus on clinical and research delivery, with the trial pipeline supplied by an experienced oncology network.
- Be the anchor physician at a site with clear room to expand from one day a week into full operation.
- Join a growing, well respected multi site oncology group that genuinely prioritises its investigators.
- Enjoy flexibility on working pattern that is difficult to find in comparable clinical research roles.
Next Steps
We are interviewing on a rolling basis with a target start date by mid-late 2026. If you meet the requirements and are open to exploring this opportunity, please apply confidentially for a discreet discussion.
Please feel free to email me for more info: elliot@plexus-partners.com
