Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

We are seeking an experienced Pharmacovigilance Physician to support safety activities for investigational and marketed products. This role focuses on risk management and medical review evaluation of individual case safety reports (ICSRs), across all stages of development and post-marketing as needed. This is a highly cross-functional role requiring strong clinical judgement and excellent scientific communication skills, including both verbal and written.

Responsibilities:

Provide medical review and evaluation of clinical trial ICSRs, ensuring timely assessment of cases
Review safety narratives, prepare Analysis of Similar Events (AOSE), and draft medical summaries to support expedited and periodic reporting
Collaborate with Safety Scientists, Clinical Development, and Medical Monitors to assess evolving safety profiles and ensure medical alignment in safety evaluations
Participate in or present at safety review meetings, Data Monitoring Committees (DMCs), and safety governance meetings, providing medical input into safety-related discussions
Analyze clinical and safety data to identify emerging safety signals and contribute to signal evaluation and communication strategies
Contribute to the preparation of Development Safety Update Reports (DSURs) and Risk Management Plans (RMPs), and Periodic Safety Update Reports (PSURs),
Contribute to the benefit-risk assessments and assist in the development, implementation, and evaluation of risk minimization measures
Review product labeling from a safety perspective and recommend appropriate updates
Provide medical expertise to support responses to safety queries from regulatory authorities
Develop company-specific MedDRA queries for signal detection
Serve as a safety representative in cross-functional teams and project meetings
Provide training and oversight of external stakeholders to promote high quality medical review, writing concise medical queries and causality assessment.
Perform additional PV related responsibilities as delegated by supervisor.

Education and Experience

MD or equivalent, with board certification in relevant specialty preferred.
Strong clinical background and familiarity with US or EU regulatory and healthcare systems
Training in or industry experience in hematology-oncology a strong plus
Minimum 10 years of experience in pharmaceutical or biotech industry, including at least 7 years in pharmacovigilance, with hands-on experience in medical review of ICSR and aggregate reports
Proficient with safety databases (e.g., Argus) and MedDRA coding
Clinical acumen with the ability to interpret safety data and assess adverse events in context
Excellent interpersonal and communication skills, including the ability to present findings to internal teams and external stakeholders
Strong analytical skills with ability to interpret complex medical and scientific data
Proficiency in medical writing, including safety narratives, ICSR evaluations, and safety reports
Ability to synthesize and communicate safety insights clearly in both written documents and verbal presentations

Personal Attributes

Meticulous attention to detail and strong quality focus
Ability to work effectively in fast paced setting and meet strict deadlines
Excellent interpersonal skills with ability to collaborate across functions
Self-motivated with capacity to work independently and as part of a team

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