If you are a current Jazz employee please apply via the Internal Career site.

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information.

The Executive Medical Director, Oncology Clinical Development, and Head of Early Oncology Programs is a senior R&D leader responsible for driving the strategy, design, and execution of early‑stage oncology clinical programs (Phase 0–2).

This role oversees a portfolio of innovative therapeutic candidates and plays a critical role in shaping the early development pipeline, integrating translational science, biomarker strategy, and clinical execution to advance assets efficiently to proof‑of‑concept and late‑stage development.

The leader partners cross‑functionally with Discovery, Translational Medicine,

Regulatory, Biostatistics, Clinical Operations, Safety, and Commercial to ensure

high‑quality decision‑making and timely progression of programs.

Essential Functions/Responsibilities

• Define the scientific and clinical development strategy for the early oncology portfolio across multiple modalities and tumor types.

Lead the design of first‑in‑human (FIH), dose‑escalation, dose‑expansion, and other early‑phase clinical trials to establish safety, PK/PD, and preliminary efficacy.

• Serve as the senior clinical voice for early oncology, influencing portfolio decisions, go/no‑go criteria, and prioritization across programs.

• Drive integration of translational and biomarker strategies to enhance patient selection and accelerate proof‑of‑mechanism/proof‑of‑concept.

Clinical Development & Execution

• Oversee medical monitoring and clinical deliverables for early‑phase oncology

studies.

• Provide expert clinical input into protocol development, IND submissions, regulatory interactions, and clinical study reports.

• Ensure early clinical programs meet the highest standards of scientific rigor, patient safety, and compliance with global regulations.

• Review and interpret emerging clinical and translational data, informing dose

selection, cohort expansion, and program advancement.

Cross‑Functional & External Collaboration

• Partner with Discovery and Translational teams to shape early pipeline strategy and mechanism‑of‑action understanding.

• Collaborate closely with Clinical Operations, Biostatistics, and Regulatory Affairs to enable efficient study start‑up, enrollment, and execution.

• Represent the company in external interactions, including KOL engagements,

academic collaborations, scientific advisory boards, and regulatory meetings (FDA, EMA, etc.).

• Provide clinical leadership for alliance partners and co‑development collaborations.

People Leadership

• Lead and mentor a team of medical directors, clinicians, and clinical scientists working across early oncology programs.

• Develop organizational capability in early development strategy, medical excellence, and decision‑making.

• Foster a culture of scientific curiosity, accountability, collaboration, and operational excellence.

Required Knowledge, Skills, and Abilities

• MD or MD/PhD required; board certification in Oncology or Hematology/Oncology.

• 10+ years of industry experience in oncology drug development, including significant leadership in early‑phase clinical development.

• Proven success advancing oncology assets from IND through Phase 1–2, including first‑in‑human studies.

• Experience interacting with global regulatory agencies on early‑phase clinical

programs.

• Deep understanding of tumor biology, translational science, PK/PD principles, and innovative clinical trial design.

• Demonstrated ability to lead clinical strategy for multiple programs simultaneously.

• Strong analytical skills and ability to interpret complex clinical and biomarker data.

• Exceptional communication skills and executive presence; capable of influencing across multiple organizational levels.

• Experience managing and developing high‑performing clinical teams.

Required/Preferred Education and Licenses

• Medical degree, MD (MD/PhD preferred) with specialized training in Hematology, Oncology;

U.S. Board Certification/Eligibility preferred

Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.

FOR US BASED CANDIDATES ONLY

Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $348,000.00 - $522,000.00

Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis.

At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.

The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here: https://careers.jazzpharma.com/benefits.html.

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