Full job description

Principal Investigator – Physician (Internal Medicine)

Opportunity: Part-Time (20-30 hours a week and flexible hours)
Type of hire: W-2 hourly as a 1099 Independent Contractor
Location: On-site in Houston, TX (Location to be announced soon)
Our client will also consider Dallas as a location so that you can gain Investigator experience in Research if you have Sub-I or no PI experience and open to relocating to Houston late summer/early spring.

Kelly Science and Clinical is hiring a PI for one of our growing Clinical Research Site Networks. Our client focuses on advancing medical innovation through high-quality, patient-centered clinical research. This is a part time need for a future new site they are developing in Houston TX. We are looking for those who are flexible with supporting projects in the meantime while expecting to start in the PI role once the site is up and running. This could require supporting Dallas TX studies or consulting with ongoing projects until later this year.

Role Summary

We are seeking an Internal Medicine physician (MD/DO) to serve as a Principal Investigator (PI) at our Houston, TX research site (opening in August 2026). This position is ideal for a physician seeking a slower pace of work and very flexible, part-time hours typically 10–20 hours/week depending on study needs. Comprehensive PI onboarding and ongoing support are provided. You will provide medical oversight for clinical trials, ensure participant safety, and help generate high-quality data—without the heavy demands of a traditional clinic schedule.

Key Responsibilities

Serve as the study physician for assigned trials; ensure participant safety and ethical conduct.
Review and confirm participant eligibility; oversee screening outcomes, AEs/SAEs, and retention trends.
Perform/oversee study-specific medical assessments (histories/physicals, concomitant meds, endpoint review).
Provide medical oversight to site staff (Sub-Investigators, CRCs, RNs, lab staff); be available for consultancy and safety questions.
Collaborate with IRBs, sponsors, and CROs; join SIVs, monitoring visits, and close-out activities as needed.
Ensure compliance with protocols, site SOPs, ICH-GCP, FDA/21 CFR, and Texas state requirements.
Review clinical data (labs, ECGs, vitals) and support timely safety reporting and documentation.
Contribute to high-quality source documentation, query resolution, and continuous improvement of site processes.

Why This Role Fits a Slower Pace

Predictable scheduling anchored to study visit calendars (no overnight call; rare urgent escalations).
Focused patient interactions with pre-screened volunteers and comprehensive study protocols.
Dedicated research team handles day-to-day coordination; you provide clinical oversight and judgment.
Flexible hours—work blocks can often be scheduled around your availability.

Training & Support

Structured PI onboarding (GCP/ICH training, protocol-specific training, mentorship from experienced PIs).
Ongoing support from seasoned clinical operations, regulatory, and QA teams.
Clear SOPs, templates, and documentation workflows to simplify your transition into research.

Qualifications — Required

MD or DO (Internal Medicine).
Active, unrestricted Texas medical license and DEA license
Interest in clinical research and comfort reviewing structured clinical data.
Strong documentation, communication, and confidentiality practices (HIPAA/PHI).

Qualifications — Preferred

Prior experience as a PI or Sub-Investigator (our client will provide training for the right candidate).
Familiarity with ICH-GCP and FDA regulations (21 CFR Parts 50, 54, 56, 312, 812).
Board certification in Internal Medicine; DEA registration if required by specific protocols.

As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan.

Why Kelly® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals—it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

Work changes everything. And at Kelly, we’re obsessed with where it can take you. To us, it’s about more than simply accepting your next job opportunity. It’s the fuel that powers every next step of your life. It’s the ripple effect that changes and improves everything for your family, your community, and the world. Which is why, here at Kelly, we are dedicated to providing you with limitless opportunities to enrich your life—just ask the 300,000 people we employ each year.

Kelly is committed to providing equal employment opportunities to all qualified employees and applicants regardless of race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or any other legally protected status, and we take affirmative action to recruit, employ, and advance qualified individuals with disabilities and protected veterans in the workforce. Requests for accommodation related to our application process can be directed to the Kelly Human Resource Knowledge Center. Kelly complies with the requirements of California’s state and local Fair Chance laws. A conviction does not automatically bar individuals from employment. Kelly participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.

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